Metal‐Free Selective and Diverse Synthesis of Three Distinct Sets of Isoindolinones from 2‐Alkynylbenzoic Acids and Amines

The metal-free selective and diverse synthesis of three distinct sets of isoindolinones from 2-alkynylbenzoic acids and amines has been achieved in a reaction-condition-controlled manner. This method exhibits valuable advantageous features such as available starting materials, broad substrate scope, excellent selectivity, good to high yields, good functional group tolerance, simple operation, high bond-forming efficiency, and step economy, thus providing a convenient and efficient access to a variety of heterocyclic compounds incorporating the bioactive isoindolinone motif.