Tumor DDR1 Deficiency Reduces Liver Metastasis by Colon Carcinoma and Impairs Stromal Reaction.
American journal of physiology Gastrointestinal and liver physiology/American journal of physiology Gastrointestinal and liver physiology(2021)
摘要
Tumor DDR1 acts as a key factor during the desmoplastic response surrounding hepatic colorectal metastasis. Hepatic sinusoidal cell-derived soluble factors stimulate tumor DDR1 activation. DDR1 modulates matrix remodeling to promote metastasis in the liver through the interaction with hepatic stromal cells, specifically liver sinusoidal endothelial cells and hepatic stellate cells.
更多查看译文
关键词
desmoplasia,discoidin domain receptor 1,hepatic stellate cells,liver metastasis from colorectal cancer,liver sinusoidal endothelial cells
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要