Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

Phil Pickford,Maria Lucey,Roxana-Maria Rujan,Emma Rose McGlone,Stavroula Bitsi,Fiona B Ashford,Ivan R Corrêa,David J Hodson,Alejandra Tomas,Giuseppe Deganutti,Christopher A Reynolds,Bryn M Owen,Tricia M Tan,James Minnion,Ben Jones,Stephen R Bloom

Molecular Metabolism（2021）

引用 10|浏览20

暂无评分

摘要

•DPP-4-resistance-conferring amino acid substitutions affect pharmacological efficacy.•GLP-1R/GCGR co-agonists with reduced β-arrestin recruitment are more effective in vivo.•Partial agonism, rather than biased agonism, is sufficient to produce these benefits.

查看译文

关键词

GLP-1,Glucagon,Oxyntomodulin,Biased agonism,Partial agonism,β-arrestin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要