Synthesis Of N-15-Labeled Heterocycles Via The Cleavage Of C-N Bonds Of Anilines And Glycine-N-15

A nitrogen replacement process that directly incorporates the N-15 atom of glycine-N-15 into anilines was reported. The process involves a Csp(2)-N bond cleavage of anilines driven by dearomatization and a Csp(3)-N bond cleavage of glycine-N-15 driven by aromatization. A variety of N-15-labeled aromatic heterocycles can be prepared via this process.