Infective endocarditis of the aortic valve in a neonate

Neonatal infective endocarditis (IE) is rare but carries a high risk of morbidity and mortality. The mainstay of treatment is antimicrobial therapy; however, treatment failure sometimes necessitates alternative management and is dictated by many factors, including the location of the lesion and its effect on cardiac function. While the tricuspid, pulmonary, and mitral valves have all been sites of IE vegetations in neonates, the aortic valve has never been reported. We describe the first reported case and the multiple complications and sequelae stemming from this unique situation.