P76.49 the Impact of Baseline Systemic Inflammatory Status Parameters in Patients Treated with EGFR-Tyrosine Kinase Inhibitors

Elevated neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR),lung immune prognostic index (LIPI) and circulating tumour cells (CTCs) are associated with inferior outcomes in non-small cell lung cancer (NSCLC). The use of these parameters in patients treated with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy is uncertain. We assessed the association of pre-treatment NLR, LIPI and CTCs on time to progression (TTP) and overall survival (OS) in patients treated with EGFR-TKIs.