Design, Synthesis And Cytotoxic Evaluation Of Diphenyl(Quinolin-8-Yl) Phosphine Oxides

A new strategy is reported for the synthesis of quinolinylphosphine oxides via the Povarov reaction between phosphorous aldimines and acetylenes. Moreover, these compounds were studied for in vitro cytotoxicity on a human lung alveolus adenocarcinoma (A 549) cell line, demonstrating strong inhibition of cell growth. (C) 2021 Elsevier Ltd. All rights reserved.