Phosphonoamidates & Phosphopnoamidines: A convenient Synthesis, Spectroscopic Properties, DFT Calculations & Pharmacological Studies

Rania Omrani,Ridha Ben Ali,Youssef Arfaoui,Anis Raddaoui, Hedia Hmani,Michèle Véronique El May,Azaiez Ben Akacha

Journal of Molecular Structure（2021）

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摘要

•Phosphonoamidates & Phosphopnoamidines: A convenient Synthesis, Spectroscopic Properties, DFT Calculations & Pharmacological Studies•IR, NMR Spectroscopy (1H, 13C, and 31P) characterization•elemental analysis and evolution study by 31P-NMR in an external lock with D2O. A DFT calculations•MAmP was characterized by analgesic activity comparable to morphine and the EAmP was characterized by specific antimicrobial activity against S. aureus.

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关键词

Phosphonoamidates,Phosphonoamidines,Density Functional Theory calculations,Evolution Study,Tautomeric equilibrium,Analgesic & antimicrobial activities,Pain behavior

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