Alternative Mechanism of Action of the DNP PtIV Prodrug: Intracellular Cisplatin Release and the Mitochondria-Mediated Apoptotic Pathway

In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.