Spontaneous Mouse Lymphoma in Patient-Derived Tumor Xenografts: the Importance of Systematic Analysis of Xenografted Human Tumor Tissues in Preclinical Efficacy Trials.
Translational oncology(2021)
摘要
Patient-derived tumor xenograft (PDX) is now largely recognized as a key preclinical model for cancer research, mimicking patient tumor phenotype and genotype. Immunodeficient mice, well-known to develop spontaneous lymphoma, are required for PDX growth. As for all animal models used for further clinical translation, a robust experimental design is strongly required to lead to conclusive results. Here we briefly report unintentional co-engraftment of mouse lymphoma during expansion of well-established PDXs to illustrate the importance of systematic check of the PDX identity to avoid misinterpretation. Besides, this quality control based on complementary approaches deserves a more detailed description in materials and methods section to ensure experimental validity and reproducibility.
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关键词
Patient-derived tumor xenograft,Immunodeficient mice,Spontaneous mouse lymphoma,Experimental bias,Reproducibility of experimental results
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