366 Adverse reproductive outcomes among women with hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic, stigmatizing disease characterized by recurrent, painful abscesses involving intertriginous skin that disproportionally affects African-Americans and women of child-bearing age. While a substantial and debilitating burden of comorbidities among people with HS has been established, there have been few studies that evaluate the effect of HS on female reproductive health and pregnancy. The aim of the present study was to investigate HS comorbidities in the electronic health records of participants in the eMERGE biorepository (project NT227). We used billing diagnosis codes to create an HS cohort and tested for association of phecodes with multivariate logistic regression, controlling for gender, ancestry and enrollment site. We identified 668 cases, of which 38.5% comprised African-American patients and 27,004 controls. Our results confirm previous studies that establish metabolic, cardiac, endocrine, gastrointestinal, rheumatologic and psychiatric comorbidities. Interestingly, we also discovered that HS cases were at a greater risk of endometriosis (OR=2.7; P<.0001), irregular menstrual cycles (OR=4.7; P<.0001), female infertility associated with anovulation (OR=3.5; P<.0001), miscarriage (OR, 2.5; P < .0001), ectopic pregnancy (OR=2.5; P<.0001), threatened premature labor (OR=2.2; P<.0001) and early onset of delivery (OR=2.8; P < .0001). These results expose the need for a multidisciplinary approach to the treatment of young women and patients of color with HS, pinpointing that the relationship between HS and adverse reproductive outcomes could represent hitherto unexplored comorbidities.