Effect of the Mutual Arrangement of Substituents in an Aminobenzoic Acid Molecule on the Analytical Performance of a Label-Free Electrochemical Immunosensor with a Covalent-Immobilized Receptor Layer

T. S. Svalova, R. A. Zaidullina, N. N. Malysheva,S. Yu. Saraeva,A. I. Matern, A. N. Kozitsina

JOURNAL OF ANALYTICAL CHEMISTRY(2021)

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摘要
We studied the effect of the mutual arrangement of substituents in an aminobenzoic acid molecule on the analytical characteristics of the determination of bacteria Staphylococcus aureus using a label-free electrochemical immunosensor. An immunosensor based on m -aminobenzoic acid demonstrated the best performance. This is apparently due to the best combination of the density of the coating formed by electrochemical deposition and the availability of carboxyl functional groups for carbodiimide cross-linking with an immunoreceptor.
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关键词
immunoassay, immunosensor, antibodies, Staphylococcus aureus, electrografting
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