GC–MS urinary metabolomics analysis of inherited metabolic diseases and stable metabolic biomarker screening by a comprehensive chemometric method

•Metabolomics coupled with chemometrics was described for stable biomarker screening.•Information-rich urinary metabolomic profiling was detected by GC–MS.•Chemometric method modeled urinary metabolomics data with desirable results.•A feasible stable biomarker screening system was developed for IMDs.