Probiotic bacteria stabilized in orally dissolving nanofibers prepared by high-speed electrospinning

Edit Hirsch,Eszter Pantea,Panna Vass,Júlia Domján,Mónika Molnár,Ágnes Suhajda,Sune K. Andersen,Tamás Vigh,Geert Verreck,György J. Marosi,Zsombor K. Nagy

Food and Bioproducts Processing（2021）

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摘要

•High-speed electrospinning was used for the scaled-up production of an orally dissolving dosage form of probiotics.•Lactobacillus paracasei was successfully encapsulated in PVA-PEO nanofibers containing stabilizing excipients.•Excipients can improve survival rate during electrospinning and long-term storage.•Excellent storage stability of encapsulated bacteria was achieved using skim milk and mannitol.

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关键词

Drying,Solid formulation,Electrospinning,Orally dissolving web,Probiotic bacteria,Lactobacillus paracasei

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