Identification and Biological Analysis of LncSPRY4‐IT1‐targeted Functional Proteins in Photoaging Skin

Skin photoaging, main causes of skin aging, is induced by chronic UV irradiation. LncSPRY4‐IT1, a broadly expressed lncRNA, takes part in various biological functions by combining with functional protein molecules. However, the role of LncSPRY4‐IT1 in skin photoaging process has not been characterized. This study is to investigate the interacting proteins of LncSPRY4‐IT1 by combining RNA pull‐down, high‐throughput, and bioinformatic analysis.