Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation

Hu Yue,Zhongjin Yang,Yitao Ou,Shuli Liang,Wenmin Deng,Hao Chen,Cheng Zhang,Lei Hua,Wenhui Hu,Ping Sun

International Immunopharmacology（2021）

引用 22|浏览8

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摘要

•15 tanshinones suppressed NLRP3 inflammasome activation.•Tanshinones reduced mitochondrial ROS production and alleviated mitochondrial damage.•Tanshinones protected mitochondria by promoting autophagy and AMPK signaling.•Dihydrotanshinone I can effectively alleviate septic and gouty inflammation.

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关键词

NLRP3 inflammasome,Tanshinone,Dihydrotanshinone I,Mitochondrial reactive-oxygen species,Septic shock,Gout

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