External validation of LCR1-LCR2, a multivariable HCC risk calculator, in patients with chronic HCV

•HCC is the fourth leading cause of cancer-related death worldwide and the fastest growing cause of cancer deaths in the USA.•The American Association for the Study of Liver Diseases recommends surveillance every 6 months only in patients with cirrhosis.•The LCR1-LCR2 algorithm is a multianalyte blood test combining proteins involved in cell repair, fibrosis and liver cancer.•The LCR1-LCR2 algorithm was able to identify patients with chronic HCV at very low risk of HCC at 5 years.•This algorithm could help clinicians to reassure a percentage of patients with chronic HCV that their risk of developing HCC remains low.