Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells.

Felix Kliewe,Andreas W Kuss,Florian Siegerist,Sindy Schröder,Sandra Schordan,Nadine Artelt,Frances Kindt,Kerstin Amann,Maja T Lindenmeyer,Karlhans Endlich,Nicole Endlich

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

Taken together, we demonstrate that Tcf21 inhibits the expression of PEC-specific markers and of the transcription factor YY1, induces MBM as well as regulates the cell cycle suggesting that Tcf21 might be important for PEC differentiation into podocyte-like cells.

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关键词

Tcf21, Parietal epithelial cells, ChIP-Seq, Differentiation, Podocyte, Transcription factors

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