Targeting hypoxia for sensitization of tumors to apoptosis enhancement through supramolecular biohybrid bacteria

Schematic illustration of the supramolecular biohybrid bacteria (SA@HU) for tumor-targeted delivery of natural antineoplastic product, ursolic acid (UA). The released UA from the biohybrid system was found to promote tumor cell apoptosis. Significant restraint of tumor progression was achieved by SA@HU due to the synergy of cellular immune activation and apoptosis enhancement.