Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine

Xian Zhou,Xuexin Feng,Dachi Wang,Deheng Chen,Gaoxing Wu,Ziqin Yan,Xilin Lyu,Huan Wang,Jin-Ming Yang,Yujun Zhao

Journal of Molecular Structure（2021）

引用 2|浏览9

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摘要

•More than 34 new analogues of Chaetominine have been synthesized.•These new analogues feature versatile electrophilic warheads.•Some analogues show improved antitumor activities in cancer cell lines compared to Chaetominine.

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关键词

Chaetominine,Cellular growth inhibition,Cancer cell line,Covalent warhead

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