Inorganofunctionalization of Ti(IV) and Zr(IV) on the MCM-41 Surface and its Interaction with a Mixed Valence Complex to use as Isoniazid Sensing

In this work, it describes the preparation of Titanium and Zirconium functionalized MCM-41 and subsequent chemical modification with nickel hexacyanoferrate. The obtained materials (MTiNiH and MZrNiH) were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), X-ray Dispersive Energy Spectroscopy (EDS), Porosity and Surface Area and Voltammetry Cyclic (VC). The cyclic voltammogram of MTiNiH and MZrNiH modified graphite paste were sensitive to isoniazid concentrations. The MTiNiH modified graphite pulp electrode showed an analytical curve with a linear response of 2.0 × 10 –5 to 5.0 × 10 –4 mol L −1 and detection limit of 6.12 × 10 –6 mol L −1 and MZrNiH modified electrode showed an analytical curve with a linear response of 3.0 × 10 –5 to 3.0 × 10 –4 mol L −1 and detection limit of 1.66 × 10 –5 mol L −1 . After catalytic electro-oxidation of isoniazid, a study of the main interferents was performed and the recovery of isoniazid in a synthetic urine sample was also evaluated. The MTiNiH and MZrNiH materials stand out for presenting good detection limit and recovery efficiency in real samples. Therefore, these materials can be considered is a strong candidate for the construction of electrochemical sensors for quick and easy detection of isoniazid.