Delay in liver transplantation referral for adolescents with biliary atresia transitioning to adult care: a slippery slope

BRITISH JOURNAL OF SURGERY(2021)

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摘要
We compared the waitlist mortality of 114 adolescent (12-17 years) and 217 adult (>= 18 years) biliary atresia candidates, and the post-transplant survival of 117 adolescent and 160 adult biliary atresia liver transplant recipients using Scientific Registry of Transplant Recipients data (2002-2018). After adjusting for Model for End-stage Liver Disease score (P = 0.001) and ascites, portal vein thrombosis, encephalopathy, life support at listing (all P >= 0.09), adults demonstrated 10.9 times higher risk of waitlist mortality vs. adolescents (95 per cent c.i. 1.55 to 76.46; P = 0.02). Adolescents exhibited superior patient (P = 0.007) and graft survival (P = 0.006).
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