Efficacy and Safety of Tramadol for Knee or Hip Osteoarthritis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Xiurui Zhang,Xiaoxiao Li,Yilin Xiong,Yilun Wang,Jie Wei,Chao Zeng,Tingting Sha,Guanghua Lei

Arthritis care & research（2023）

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摘要

Only tramadol 300 mg/day showed minimal improvement in pain and function but with increasing AEs compared with placebo. Tramadol may not be sufficiently recommended for knee or hip OA based on the presented evidence, especially in patients with the risk of gastrointestinal and CNS AEs.

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关键词

network meta-analysis,osteoarthritis,tramadol

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