DUSP22 rearrangement in primary cutaneous T cell lymphoma with features intermediate between mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis.

A 79-year-old man with a long-standing history of eczema with no other remarkable medical history came to our hospital complaining of a round, non-ulcerated, 3-cm-diameter, tumoral nodule of sudden growth (Figure 1A, 1B). Histological study revealed a CD30+, CD3+ biphasic lymphoid infiltrate with large cells in the dermis and smaller lymphocytes that exhibited a striking epidermotropism that was also present in the contiguous epidermis, where it had a pagetoid pattern (Figure 2A, 2B, 2C, 2D, 2E). TCR-ß was positive and CD8 was focally and weakly positive. CD4, CD20, ALK, TIA1, Perforin, Granzyme, PSTAT3 and TCR-γ were all negative.