Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents.

Psychological medicine(2021)

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摘要
Disturbances in HPA-axis functioning are already evident early after CM exposure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose-response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.
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关键词
Anxiety perception,Trier Social Stress Test for children (TSST-C),child abuse,childhood maltreatment (CM),cortisol,dose–response,hypothalamic–pituitary–adrenal (HPA)-axis,youth psychopathology
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