Limited-stage small cell lung cancer: Outcomes associated with prophylactic cranial irradiation over a 20-year period at the Princess Margaret Cancer Centre

Michael Yan,Tzen S. Toh,Patricia E. Lindsay,Jessica Weiss,Katrina Hueniken,Christy Yeung,Vijithan Sugumar,Dixon Pinto,Tony Tadic,Alexander Sun,Andrea Bezjak,John Cho,Srinivas Raman,Meredith Giuliani,Fabio Ynoe Moraes,Geoffrey Liu,Andrew J. Hope,Benjamin H. Lok

Clinical and Translational Radiation Oncology（2021）

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摘要

•Prophylactic cranial irradiation (PCI) was more commonly used in younger patients.•PCI utilization rates did not change throughout our 20-year institutional experience.•PCI was associated with improved OS and lower brain metastasis risk, independent of MRI follow-up or era of treatment.•For LS-SCLC patients with good thoracic response, PCI remains the standard-of-care.

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关键词

Small-cell lung cancer,Prophylactic cranial irradiation,Limited-stage

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