MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too

Salvatore Collura,Carmen Ciavarella,Cristina Morsiani,Ilenia Motta,Sabrina Valente,Enrico Gallitto,Mohammad Abualhin,Rodolfo Pini,Francesco Vasuri,Claudio Franceschi,Miriam Capri,Mauro Gargiulo,Gianandrea Pasquinelli

Mechanisms of Ageing and Development（2021）

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摘要

•Epigenetic structure of arteries as variable behind Atherosclerosis development.•MiR-profiling of normal carotid and abdominal aorta arteries is similar.•MiR-profiling is different in normal femoral vs normal aorta/carotid arteries.•MiRs-155-5p, -27a-5p, -139-5p characterize normal and pathological arteries.•CD44, E-cadherin, vimentin, and SLUG expressions characterize each arteria/atheroma.

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关键词

Normal arteries,Atherosclerosis,Biomarkers,Aging,microRNAs

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