Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma

Brian S Perez,Ka Man Wong,Erin K Schwartz,Rafael E Herrera,Devin A King,Pablo E García-Nieto,Ashby J Morrison

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2021）

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摘要

•Across the genome, 6-4PP and CPD lesions have broadly similar distributions.•Chromatin at bivalent and Polycomb-repressed enhancers are differentially susceptible to 6-4PPs.•Genes and enhancers more susceptible to 6-4PPs than CPD are associated with cell viability and immune-related pathways.•Both 6-4PP and CPD lesions correlate with C > T mutation rates across the genome.

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关键词

UV susceptibility,6-4PP,UV-induced mutations,Melanoma,Excision repair,CPD

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