Cerebrospinal fluid cytokine, chemokine, and SARS-CoV-2 antibody profiles in children with neuropsychiatric symptoms associated with COVID-19

Binh Ngo,Stacey A Lapp,Benjamin Siegel,Vikash Patel,Laila Hussaini,Sonali Bora,Bryan Philbrook, Kristin Weinschenk,Laura Wright,Evan J Anderson,Christina A Rostad,Grace Y Gombolay

Multiple Sclerosis and Related Disorders（2021）

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摘要

•CSF cytokines/chemokines are unknown in pediatric COVID-19.•We discuss neurological and psychiatric symptoms in five children with COVID-19.•CSF chemokines and SARS-CoV-2 antibodies are elevated.•SARS-CoV-2 antibodies strongly correlate with pro-inflammatory CSF cytokines.

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关键词

Pediatric COVID-19,SARS-CoV-2,Coronavirus,Cytokines,Chemokines,Cerebrospinal fluid,Psychiatric symptoms

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