CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs.

Mostafa G Aly,Eman H Ibrahim,Hristos Karakizlis,Rolf Weimer,Gerhard Opelz,Christian Morath,Martin Zeier,Naruemol Ekpoom,Volker Daniel

Frontiers in immunology（2021）

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摘要

These findings suggest that CD19+IL-10+ Bregs and CD4+CD25+CD127-Foxp3+ Tregs behave in opposite ways during the early posttransplant period, possibly due to a predominant negative impact of high doses of immunosuppressants on Tregs. CD19+IL-10+Bregs do not seem to be suppressed by antibody induction and early potent immunosuppression with chemical drugs.

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Bregs,CD8+ Tregs,CD8+CD28- Tregs,IL-10+ Bregs,Tregs,renal transplantation

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