MicroRNA-128 inhibits mitochondrial biogenesis and function via targeting PGC1α and NDUFS4

Kritika Sharma,Amit Chandra,Yasha Hasija,Neeru Saini

Mitochondrion（2021）

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摘要

•MiR-128 directly targets PGC1α and downregulates mitochondrial biogenesis.•MiR-128 inhibits mitochondrial fusion and induces fission.•MiR-128 promotes impairment in cellular ATP production by targeting NDUFS4.•Inhibition of miR-128 reverse the HFD induced mitochondrial dysfunction.

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关键词

COX1,COX2,ND1,UTR

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