Identification of novel GPCR partners of the central melanocortin signaling

Yunpeng Li,Xiaozhu Wang,Liumei Lu,Meng Wang,Yue Zhai,Xiaolu Tai,Diliqingna Dilimulati,Xiaowei Lei,Jing Xu,Cong Zhang,Yanbin Fu,Shen Qu,Qingfeng Li,Chao Zhang

Molecular Metabolism（2021）

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摘要

•More GPCRs are found in the neurons than other cell types in the mouse hypothalamus, and their functions are significantly enriched in energy homeostasis and metabolism.•A total of 23 and 32 GPCRs are confirmed to be novel interacting partners of MC3R and MC4R in vitro, respectively.•The hetero-dimerization of identified GPCRs with MC3R and MC4R alters the signal transduction and surface translocation.

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关键词

MC3R,MC4R,GPCR,Single cell RNA-Seq,Energy homeostasis,Dimerization

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