The PICK1/TLR4 complex on microglia is involved in the regulation of LPS-induced sepsis-associated encephalopathy

Lu Wang,Feihong Lin,Miao Ren,Xia Liu,Wenjing Xie,Anqi Zhang,Meizi Qian,Yunchang Mo,Junlu Wang,Ya Lv

International Immunopharmacology（2021）

引用 9|浏览22

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摘要

•The involvement of PICK1 in Sepsis-associated Encephalopathy was first identified.•Deficiency of PICK1 aggravates inflammatory damage and overactivation of the TLR4 pathway.•PICK1 plays a protective role in Sepsis-associated Encephalopathy by forming a complex with TLR4.

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关键词

Sepsis-associated encephalopathy,LPS,Microglia,Neuroinflammation,PICK1,TLR4

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