Metabolomics analysis of cucumber fruit in response to foliar fertilizer and pesticides using UHPLC-Q-Orbitrap-HRMS

•Mixed use of pesticides and foliar fertilizer increased the contents of organic acids and antioxidant.•Pesticides used without foliar fertilizer up-regulated shikimate-phenylpropanoid pathway.•Mixed use of pesticides and foliar fertilizer up-regulated tricarboxylic acid cycle.•Mixed use of pesticides and foliar fertilizer significantly promoted the dissipation of pesticides.