Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat

Nagalakshmi Balasubramanian,Gouri Jadhav,Amul J Sakharkar

Mitochondrion（2021）

引用 9|浏览13

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摘要

•Repeated mild traumatic brain injuries (rMTBI) decreased TFAM levels.•rMTBI-induced nuclear DNA hypermethylation declined TFAM levels.•Mitochondrial DNA (mtDNA) hypomethylation after rMTBI attenuated TFAM binding.•Low TFAM occupancy on hypomethylated mtDNA altered mitochondrial biogenesis.•Methionine treatment restored rMTBI-induced mitochondrial biogenesis via mtDNA methylation.

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关键词

Mild traumatic brain injury,Mitochondrial biogenesis,Mitochondrial transcription factor A,DNA methylation,Heavy strand promoter,mitochondrial DNA

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