Localization Defines Streptozotocin/5-FU Response in Primary Pancreatic Neuroendocrine Tumours.

Dominik Reher,Uli Fehrenbach,Antonin Kayser,Ulrich-Frank Pape,Frank Oliver Henes,Birgit Cremer,Dieter Hörsch,Jakob Izbicki,Ansgar Wilhelm Lohse,Anja Rinke,Jörg Schrader

Neuroendocrinology（2022）

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摘要

STZ/5-FU can achieve disease stabilization in a high proportion of metastatic pNET patients. In the majority of cases however it does not induce substantial downsizing of the primary tumour, thus possibly limiting its potential as conversion chemotherapy. Furthermore, the difference in response rate observed between different primary tumour locations warrants further exploration.

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关键词

5-Fluorouracil,Neoadjuvant,Pancreatic neuroendocrine tumours,Primary tumour,Streptozocin

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