Therapeutic Efficacy of Human Monoclonal Antibodies Against Andes Virus Infection in Syrian Hamsters.
Emerging infectious diseases(2021)
摘要
Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.
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关键词
recombinant human monoclonal antibodies,Andes orthohantavirus,Syrian hamster,viruses,zoonoses
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