Multicenter study on recent portal venous system thrombosis associated with cytomegalovirus disease

•Patients with CMV-associated PVT were younger, had higher heart rate and body temperature, and elevated serum ALT.•The prothrombin G20210A gene variant is associated with CMV disease in patients with PVT.•Diagnosing CMV disease in a patient with PVT does not deter from performing a complete screening of risk factors for thrombosis.•CMV disease might trigger PVT in susceptible patients.•Patients with CMV-associated PVT have similar thrombosis extension and outcome as patients with PVT without CMV disease.