Antagonizing astrocytic platelet activating factor receptor-neuroinflammation for total flavone of epimedium in response to cuprizone demyelination

Zhao Meng-Ru,Sui Ruo-Xuan,Yu Ming-Yang,Tian Tong,Zhang Lei,Yang Ying-Bo,Xiao Bao-Guo

International Immunopharmacology（2021）

引用 6|浏览16

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摘要

•TFE improved behavioural performance and promoted remyelination via oral administration.•TFE promoted astrocyte activation and neurotrophic factor production.•TFE improved astrocyte-derived inflammatory and nutritional microenvironment.•TFE antagonized PAF-PAFR pathway as a new natural PAFR antagonist.

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关键词

Total flavone of Epimedium,Cuprizone-induced demyelinating model,Platelet activating factor receptor,Neuroinflammation,Astrocytes

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