Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis

Yara-Natalie Abo,Nigel Curtis,Joshua Osowicki,Gabrielle Haeusler,Rachael Purcell,Seilesh Kadambari,Matthias De Wachter,Koen Vanden Driessche,Sven Dekeyzer,Lee Coleman,Nigel Crawford,Steve Graham,Ben Marais,Amanda Gwee

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY（2021）

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摘要

Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.

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关键词

central nervous system tuberculosis, infliximab, paradoxical reaction, tuberculous meningitis

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