Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics

Jonas Ellegaard Nielsen,Raluca Georgiana Maltesen,Jesper F Havelund,Nils J Færgeman,Charlotte Held Gotfredsen,Karsten Vestergård,Søren Risom Kristensen,Shona Pedersen

Metabolism Open（2021）

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摘要

Using a combination of LC-MS and NMR methodologies we identified several altered mechanisms possibly related to AD pathology. EVs require additional optimization prior to their possible utilization as a biological material for AD-related metabolomics studies.

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关键词

Alzheimer,Metabolites,Blood,Extracellular vesicles,Mass spectrometry,Nuclear magnetic resonance

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