12-Deoxyphorbol 13-acetate inhibits RANKL-induced osteoclastogenesis via the attenuation of MAPK signaling and NFATc1 activation

Delong Chen,Feifan Chu,Gangyu Zhang,Qingqing Wang,Ying Li,Meng Zhang,Qi He,Junzheng Yang,Haibin Wang,Ping Sun,Jiake Xu,Peng Chen

International Immunopharmacology（2021）

引用 3|浏览13

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摘要

•DPA inhibits RANKL-induced osteoclast formation and function.•DPA attenuates MAPK signaling, calcium oscillations and NFATc1 activation.•DPA protects against OVX-induced bone loss.

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关键词

12-Deoxyphorbol 13-acetate,Osteoporosis,Osteoclast,NFATc1,MAPK

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