Self-Assembly Of Artificial Sweetener Aspartame Adversely Affects Phospholipid Membranes: Plausible Reason For Its Deleterious Effects

The prolonged intake of the artificial sweetener aspartame is known to have deleterious effects. Our biophysical experimentations indicate that aspartame forms self-assembled cytotoxic fibrillar etiologies that affect the intrinsic integrity of the phospholipid membrane bilayer through electrostatic interaction and hydrophobic insertion, thereby making the membrane less rigid and more heterogeneous.