Dissolving the cytosolic bacteria in non-immune cells

How do mammalian non-immune cells manage to control intracellular pathogens? With a genome-wide CRISPR-Cas9 screen, Gaudet et al. identified apolipoprotein L3 (APOL3), induced by IFN-gamma, as a crucial host factor targeting and killing intracellular bacteria and thus revealing a new IFN-gamma-dependent innate defense mechanism in non immune cells.