Tumor vascular remodeling by thrombospondin-1 enhances drug delivery and antineoplastic activity

•The abnormal morphological and functional properties of the tumor vasculature are a major hindrance to the distribution and efficacy of antineoplastic therapies.•This study describes the ability of a domain of the matricellular protein thrombospondin-1 (TSP-1) to remodel the tumor vasculature, restrain tumor growth, and boost drug delivery and efficacy.•These findings indicate a new role for TSP-1 in tumor vessel remodeling and open new perspectives for the development of TSP-1-based therapies.