A Panel of Engineered Ubiquitin Variants Targeting the Family of Domains Found in Ubiquitin Specific Proteases (DUSPs)

Jason Q Tang,Gianluca Veggiani,Alex Singer,Joan Teyra,Jacky Chung,Sachdev S Sidhu

Journal of Molecular Biology（2021）

引用 3|浏览17

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摘要

•We developed a new phage-displayed UbV library to target DUSPs.•The library yielded tight and specific DUSP-binding UbVs.•A DUSP-binding UbV inhibited the catalytic activity of USP15, USP11 and USP20

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关键词

Ubiquitin,Phage display,DUSP,Deubiquitinases,Enzyme inhibition

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