Neurotrophin-3 attenuates human peripheral blood T cell and monocyte activation status and cytokine production post stroke

Mark Lukas Müller, Lars Peglau,Lawrence D F Moon,Stefan Groß,Juliane Schulze,Johanna Ruhnau,Antje Vogelgesang

Experimental Neurology（2022）

引用 5|浏览18

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摘要

•Neurotrophin-3 (NT-3) modulates activation status of PBMCs ex vivo•NT-3 attenuated cytokine secretion and of activation marker expression for human PBMC•Expression level of NT-3 receptor TrkC for PBMCs is dependent on age of control•Stimulation with LPS modulates TrkC expression level of PBMCs from controls•Immune modulation as mechanism for therapeutic benefit of NT-3 remains to be assessed

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关键词

NT-3,Stroke,T cell,Cytokine,TrkC

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