Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel.

Johannes Reiner,Peggy Berlin,Jascha Held,Johanna Thiery,Jolanta Skarbaliene, Jonathan Griffin,Wayne Russell,Per-Olof Eriksson,Mark Berner-Hansen,Luise Ehlers,Brigitte Vollmar,Robert Jaster,Maria Witte,Georg Lamprecht

JPEN. Journal of parenteral and enteral nutrition（2022）

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摘要

Dapiglutide possesses specific and potent GLP-1R and GLP-2R agonist effects in rodents. In the murine SB model, combined unimolecular GLP-1R and GLP-2R stimulation with dapiglutide potently attenuates intestinal insufficiency and potentially also IF.

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关键词

GLP-1,GLP-2,gastroenterology,intestinal failure,parenteral nutrition,short bowel syndrome,surgery

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