CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium.

Carolina Estevao,Chantelle E Bowers, Ding Luo,Mosharraf Sarker,Alexandra Eva Hoeh,Karen Frudd,Patric Turowski,John Greenwood

Brain, behavior, & immunity - health（2021）

引用 20|浏览7

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摘要

These results show that CCL4 can modify BBB function and may contribute to disease pathogenesis.

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关键词

BBB, blood-brain barrier,CCL4,CNS, central nervous system,Chemokines,EC, endothelial cell,F-actin, filamentous actin,Inflammation,MAPK, mitogen-activated protein kinase,Neurogenesis,Neuroinflammation,Permeability,SDS-PAGE, Sodium dodecyl sulphate-polyacrylamide gel electrophoresis,VE-cadherin, vascular endothelial cadherin,ZO-1, zonula occludens-1,hCMEC/D3, immortalized human cerebral microvascular endothelial cell line

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