Aberrant expression of TMEM205 signaling promotes platinum resistance in ovarian cancer: An implication for the antitumor potential of DAP compound

Corinne A Calo,Brentley Q Smith,Kalpana Deepa Priya Dorayappan,Uksha Saini,Michelle Lightfoot,Vincent Wagner,Deepika Kalaiyarasan,Casey Cosgrove,Qi-En Wang,G Larry Maxwell,Tamás Kálai,Periannan Kuppusamy,David E Cohn,Karuppaiyah Selvendiran

Gynecologic Oncology（2022）

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摘要

•TMEM205 and CD1B membrane proteins are highly elevated in OC tissues.•TMEM205 mediated exosome secretion associated with platinum resistance in OC.•L-2663 could effectively suppress platinum resistance in OC by inhibiting TMEM205.

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关键词

Ovarian cancer,Platinum resistant,Exosomes,TMEM205,Small molecule inhibitor

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